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Article

Design and validation of a high-throughput assay to detect codon 146 polymorphisms in the caprine prion protein gene.

Analytical biochemistry - 15 Oct 2009

Arrizubieta María J, Kanata Eirini, Keklikoglou Ioanna, Papasavva-Stylianou Penelope, Toumazos Pavlos, Panagiotidis Cynthia H, Sklaviadis Theodoros

Abstract excerpt

In sheep, scrapie susceptibility is so strongly associated with single nucleotide polymorphisms (SNPs) in the gene encoding the prion protein (PrP) that this linkage constitutes the basis for selective breeding strategies directed toward controlling the disease. For goats, in contrast, the association between scrapie susceptibility/resistance and variations in the PrP gene is far weaker, with only a few...

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PMID: 19559665
DOI: 10.1016/j.ab.2009.06.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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