Exploring the genetic variability of the PRNP gene at codons 127, 142, 146, 154, 211, 222, and 240 in goats farmed in the Lombardy Region, Italy.

doi:10.1186/s13567-024-01353-3

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Article

Exploring the genetic variability of the PRNP gene at codons 127, 142, 146, 154, 211, 222, and 240 in goats farmed in the Lombardy Region, Italy.

Veterinary research - 6 Aug 2024

Ferrari Carlotta, Punturiero Chiara, Milanesi Raffaella, Delledonne Andrea, Bagnato Alessandro, Strillacci Maria G

Abstract excerpt

Scrapie is a transmissible spongiform encephalopathy affecting sheep and goats. The prion protein-encoding gene (PRNP) plays a crucial role in determining susceptibility and resistance to scrapie. At the European level, surveillance of scrapie is essential to prevent the spread of the disease to livestock. According to the Regulation EU 2020/772 polymorphisms K222, D/S146 could function as resistance alleles in...

Topics

Animals
Italy
Goats
Goat Diseases
Prion Proteins
Scrapie
Codon
Genetic Variation
Polymorphism, Single Nucleotide

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Identifiers

PMID: 39107851
DOI: 10.1186/s13567-024-01353-3
PMCID: PMC11304840

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