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Article

Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis.

Cancer science - 1 Jun 2021

Kanazawa Kosuke, Kishimoto Kazuhiro, Nomura Miyuki, Kurosawa Koreyuki, Kato Hiroyuki, Inoue Yui, Miura Koh, Fukui Katsuya, Yamashita Yoji, Sato Ikuro, Tsuji Hiroyuki, Watanabe Toshio, Tanaka Takuji, Yasuda Jun, Tanuma Nobuhiro, Shima Hiroshi

Abstract excerpt

According to TCGA database, mutations in PPP6C (encoding phosphatase PP6) are found in c. 10% of tumors from melanoma patients, in which they coexist with BRAF and NRAS mutations. To assess PP6 function in melanoma carcinogenesis, we generated mice in which we could specifically induce BRAF(V600E) expression and delete Ppp6c in melanocytes. In these mice, melanoma susceptibility following UVB irradiation...

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Source

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Identifiers

PMID: 33743547
DOI: 10.1111/cas.14895
PMCID: PMC8177767

Genes

BRAF
NRAS
PPP6C

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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