Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene of the month: STK11.

Journal of clinical pathology - 1 Nov 2021

Zyla Roman E, Hahn Elan, Hodgson Anjelica

Abstract excerpt

STK11 encodes for the protein liver kinase B1, a serine/threonine kinase which is involved in a number of physiological processes including regulation of cellular metabolism, cell polarity and the DNA damage response. It acts as a tumour suppressor via multiple mechanisms, most classically through AMP-activated protein kinase-mediated inhibition of the mammalian target of rapamycin signalling pathway. Germline...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinase Kinases
Share to Cancer Genomics and Diagnostics
Share to Cancer-related Molecular Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic factors in colorectal cancer

Share to Mutation

Share to Neoplasms

Share to Peutz-Jeghers Syndrome

Share to Protein Serine-Threonine Kinases

Source

Identifiers

PMID: 34479873
DOI: 10.1136/jclinpath-2021-207906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene of the month: STK11.PMID 34479873Read ↗

Emerging Therapeutic Implications of STK11 Mutation: Case Series.Semantic proximity Read ↗

Relative frequency and morphology of cancers in STK11 mutation carriers.Semantic proximity Read ↗

An exploration of genotype-phenotype link between Peutz-Jeghers syndrome and STK11: a review.Semantic proximity Read ↗

A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma.Semantic proximity Read ↗

Lung cancer as a predominant feature in a patient with Peutz-Jeghers syndrome: Case report.Semantic proximity Read ↗

Gene symbol: STK11. Disease: Peutz-Jeghers Syndrome.Semantic proximity Read ↗

Peutz-Jeghers Syndrome: A Comprehensive Review of Genetics, Clinical Features, and Management ApproachesSemantic proximity Read ↗

STK11/LKB1 Modulation of the Immune Response in Lung Cancer: From Biology to Therapeutic Impact.Semantic proximity Read ↗

Peutz-Jeghers syndrome without STK11 mutation may correlate with less severe clinical manifestations in Chinese patients.Semantic proximity Read ↗

Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome.Semantic proximity Read ↗

The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progressionSemantic proximity Read ↗

Prevalence and clinico-morphological correlates of STK11 mutations in a large cohort of NSCLC lung adenocarcinomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.