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Article

The Transcriptional Landscape of p53 Signalling Pathway

18 May 2017

Abstract excerpt

Although recent cancer genomics studies have identified a large number of genes that were mutated in human cancers, p53 remains as the most frequently mutated gene. To further elucidate the p53-signalling network, we performed transcriptome analysis on 24 tissues in p53 +/+ or p53 −/− mice after whole-body X-ray irradiation. Here we found transactivation of a total of 3551 genes in one or more of the 24 tissues...

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PMID: 28558959
DOI: 10.1016/j.ebiom.2017.05.017

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