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Article

Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation

18 Jun 2021

Abstract excerpt

deficiency induces constitutive activation of cAMP/CREB-mediated transcription by a family of three CREB-regulated transcription coactivators (CRTC1-3). However, the significance and mechanism of CRTC activation in promoting the aggressive phenotype of LKB1-null cancer remain poorly characterized. Here, we observed overlapping CRTC expression patterns and mild growth phenotypes of individual CRTC-knockouts in...

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PMID: 34142658
DOI: 10.7554/elife.66095

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