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Article

Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer.

Oncogene - 18 Mar 2010

Komiya T, Coxon A, Park Y, Chen W-D, Zajac-Kaye M, Meltzer P, Karpova T, Kaye F J

Abstract excerpt

Activation of Crtc1 (also known as Mect1/Torc1) by a t(11;19) chromosomal rearrangement underlies the etiology of malignant salivary gland tumors. As LKB1 is a target for mutational inactivation in lung cancer and was recently shown to regulate hepatic Crtc2/CREB transcriptional activity in mice, we now present evidence suggesting disruption of an LKB1/Crtc pathway in cancer. Although Crtc1 is preferentially...

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Source

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Identifiers

PMID: 20010869
DOI: 10.1038/onc.2009.453
PMCID: PMC7227613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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