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Article

cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth.

The Journal of clinical investigation - 1 Jun 2016

Chen Zirong, Li Jian-Liang, Lin Shuibin, Cao Chunxia, Gimbrone Nicholas T, Yang Rongqiang, Fu Dongtao A, Carper Miranda B, Haura Eric B, Schabath Matthew B, Lu Jianrong, Amelio Antonio L, Cress W Douglas, Kaye Frederic J, Wu Lizi

Abstract excerpt

The LKB1 tumor suppressor gene is frequently mutated and inactivated in non-small cell lung cancer (NSCLC). Loss of LKB1 promotes cancer progression and influences therapeutic responses in preclinical studies; however, specific targeted therapies for lung cancer with LKB1 inactivation are currently unavailable. Here, we have identified a long noncoding RNA (lncRNA) signature that is associated with the loss of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27140397
DOI: 10.1172/JCI85250
PMCID: PMC4887185

Genes

NONO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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