Article
3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer.
Cancer research - 15 Feb 2021
Peck Barrie, Bland Philip, Mavrommati Ioanna, Muirhead Gareth, Cottom Hannah, Wai Patty T, Maguire Sarah L, Barker Holly E, Morrison Eamonn, Kriplani Divya, Yu Lu, Gibson Amy, Falgari Giulia, Brennan Keith, Farnie Gillian, Buus Richard, Marlow Rebecca, Novo Daniela, Knight Eleanor, Guppy Naomi, Kolarevic Daniela, Susnjar Snezana, Milijic Natasa Medic, Naidoo Kalnisha, Gazinska Patrycja, Roxanis Ioannis, Pancholi Sunil, Martin Lesley-Ann, Holgersen Erle M, Cheang Maggie C U, Noor Farzana, Postel-Vinay Sophie, Quinn Gerard, McDade Simon, Krasny Lukas, Huang Paul, Daley Frances, Wallberg Fredrik, Choudhary Jyoti S, Haider Syed, Tutt Andrew N, Natrajan Rachael
Abstract excerpt
Triple-negative breast cancers (TNBC) are resistant to standard-of-care chemotherapy and lack known targetable driver gene alterations. Identification of novel drivers could aid the discovery of new treatment strategies for this hard-to-treat patient population, yet studies using high-throughput and accurate models to define the functions of driver genes in TNBC to date have been limited. Here, we employed...
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