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Cluster Analysis of Inflammatory Biomarker Expression in the International Severe Asthma Registry

19 Mar 2021

Abstract excerpt

BACKGROUND: Allergy, eosinophilic inflammation, and epithelial dysregulation are implicated in severe asthma pathogenesis. OBJECTIVE: We characterized biomarker expression in adults with severe asthma. METHODS: Within the International Severe Asthma Registry (ISAR), we analyzed data from 10 countries in North America, Europe, and Asia, with prespecified thresholds for biomarker positivity (serum IgE ≥ 75 kU/L,...

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PMID: 33744476
DOI: 10.1016/j.jaip.2021.02.059

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