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Article

Massive PD-L1 and CD8 double positive TILs characterize an immunosuppressive microenvironment with high mutational burden in lung cancer.

Journal for immunotherapy of cancer - 1 Jun 2021

Zhang Libin, Chen Yanhui, Wang Han, Xu Zheyuan, Wang Yang, Li Sixing, Liu Jun, Chen Yun, Luo Hongli, Wu Lijia, Yang Ying, Zhang Henghui, Peng Hao

Abstract excerpt

BACKGROUND: Programmed cell death ligand 1 (PD-L1) expressed on tumor and immune cells are both associated with the response to programmed cell death 1 (PD-1) pathway blockade therapy. Here, we examine the role of CD8+PD-L1+ tumor-infiltrating lymphocyte (Tils) in the tumor microenvironment of non-small cell lung cancer (NSCLC). METHODS: Tumor tissue samples of a total of 378 patients from two NSCLC cohorts were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34140315
DOI: 10.1136/jitc-2021-002356
PMCID: PMC8212410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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