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Article

TP53 Mutation and Tumor-Infiltrating Lymphocytes as Predictors of PD-1/PD-L1 Inhibitor Efficacy in PD-L1-High Advanced NSCLC.

Cancer reports (Hoboken, N.J.) - 1 Aug 2026

Yan Hui, Xu Qian, Zheng Yushuang, Shen Meng, Li Dapeng

Abstract excerpt

BACKGROUND: Programmed death-ligand 1 (PD-L1) expression is widely used to guide immune checkpoint inhibitor (ICI) therapy in advanced nonsmall cell lung cancer (NSCLC); however, substantial heterogeneity in clinical outcomes persists among patients with high PD-L1 expression. Reliable biomarkers for further stratifying this population are still lacking. This study investigated whether genomic alterations and...

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Share to B7-H1 Antigen
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Checkpoint Inhibitors

Share to Lymphocytes, Tumor-Infiltrating

Share to Programmed Cell Death 1 Receptor

Share to Progression-Free Survival

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Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 42595871
DOI: 10.1002/cnr2.70648
PMCID: PMC13473177

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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