Genomic profiles and their associations with TMB, PD-L1 expression, and immune cell infiltration landscapes in synchronous multiple primary lung cancers.

doi:10.1136/jitc-2021-003773

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Article

Genomic profiles and their associations with TMB, PD-L1 expression, and immune cell infiltration landscapes in synchronous multiple primary lung cancers.

Journal for immunotherapy of cancer - 1 Dec 2021

Hu Chunhong, Zhao Lishu, Liu Wenliang, Fan Songqing, Liu Junqi, Liu Yuxuan, Liu Xiaohan, Shu Long, Liu Xianling, Liu Ping, Deng Chao, Qiu Zhenhua, Chen Chen, Jiang Yi, Liang Qingchun, Yang Lingling, Shao Yang, He Qiongzhi, Yu Danlei, Zeng Yue, Li Yizheng, Pan Yue, Zhang Sujuan, Shi Shenghao, Peng Yurong, Wu Fang

Abstract excerpt

BACKGROUND: Diagnosing and treating patients with multiple primary lung cancers (MPLCs) bring challenges to the clinic, and the preliminary evidence has revealed unsatisfying outcomes after targeted therapy and immunotherapy. Therefore, we surveyed genomic profiles of MPLCs and their possible associations with tumor mutation burden (TMB), programmed death-ligand 1 (PD-L1), and the immune cell infiltration...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34887263
DOI: 10.1136/jitc-2021-003773
PMCID: PMC8663088

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