Article
PD-L1 expression and T cells infiltration in patients with uncommon EGFR-mutant non-small cell lung cancer and the response to immunotherapy.
Lung cancer (Amsterdam, Netherlands) - 1 Apr 2020
Chen Kaiyan, Cheng Guoping, Zhang Fanrong, Zhu Guanxia, Xu Yanjun, Yu Xiaoqing, Huang Zhiyu, Fan Yun
Abstract excerpt
OBJECTIVES: The efficacy of immunotherapy in epidermal growth factor receptor (EGFR)-activating non-small cell lung cancer (NSCLC) is limited. However, a series of patients with uncommon EGFR alterations was reported to derive clinical benefit from PD-1 blockade. To characterize the tumor immune microenvironment, we retrospectively evaluated tumor PD-L1 expression and T cells infiltration among NSCLC patients...
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