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Article

Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling.

Nature communications - 16 Jun 2021

de la Calle Arregui Celia, Plata-Gómez Ana Belén, Deleyto-Seldas Nerea, García Fernando, Ortega-Molina Ana, Abril-Garrido Julio, Rodriguez Elena, Nemazanyy Ivan, Tribouillard Laura, de Martino Alba, Caleiras Eduardo, Campos-Olivas Ramón, Mulero Francisca, Laplante Mathieu, Muñoz Javier, Pende Mario, Sabio Guadalupe, Sabatini David M, Efeyan Alejo

Abstract excerpt

The mechanistic target of rapamycin complex 1 (mTORC1) integrates cellular nutrient signaling and hormonal cues to control metabolism. We have previously shown that constitutive nutrient signaling to mTORC1 by means of genetic activation of RagA (expression of GTP-locked RagA, or RagAGTP) in mice resulted in a fatal energetic crisis at birth. Herein, we rescue neonatal lethality in RagAGTP mice and find...

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Identifiers

PMID: 34135321
DOI: 10.1038/s41467-021-23857-8
PMCID: PMC8209044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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