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Article

Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply.

Autophagy - 1 Jan 2018

Zhang Hao, Yan Shengmin, Khambu Bilon, Ma Fengguang, Li Yong, Chen Xiaoyun, Martina Jose A, Puertollano Rosa, Li Yu, Chalasani Naga, Yin Xiao-Ming

Abstract excerpt

Normal metabolism requires a controlled balance between anabolism and catabolism. It is not completely known how this balance can be retained when the level of nutrient supply changes in the long term. We found that in murine liver anabolism, as represented by the phosphorylation of RPS6KB (ribosomal protein S6 kinase), was soon elevated while catabolism, as represented by TFEB (transcription factor EB)-directed...

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Feedback, Physiological

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Share to Mechanistic Target of Rapamycin Complex 1

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Source

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Identifiers

PMID: 30044707
DOI: 10.1080/15548627.2018.1490850
PMCID: PMC6135624

Genes

TFEB
MTOR
RRAGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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