Article
Epigenetic landscapes of intracranial aneurysm risk haplotypes implicate enhancer function of endothelial cells and fibroblasts in dysregulated gene expression.
BMC medical genomics - 16 Jun 2021
Poppenberg Kerry E, Zebraski Haley R, Avasthi Naval, Waqas Muhammad, Siddiqui Adnan H, Jarvis James N, Tutino Vincent M
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified many single nucleotide polymorphisms (SNPs) associated with increased risk for intracranial aneurysm (IA). However, how such variants affect gene expression within IA is poorly understood. We used publicly-available ChIP-Seq data to study chromatin landscapes surrounding risk loci to determine whether IA-associated SNPs affect functional elements that...
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