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Article

Epigenetic landscapes suggest that genetic risk for intracranial aneurysm operates on the endothelium.

BMC medical genomics - 30 Oct 2019

Poppenberg Kerry E, Jiang Kaiyu, Tso Michael K, Snyder Kenneth V, Siddiqui Adnan H, Kolega John, Jarvis James N, Meng Hui, Tutino Vincent M

Abstract excerpt

BACKGROUND: Genetics play an important role in intracranial aneurysm (IA) pathophysiology. Genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) that are linked to IA but how they affect disease pathobiology remains poorly understood. We used Encyclopedia of DNA Elements (ENCODE) data to investigate the epigenetic landscapes surrounding genetic risk loci to determine if...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31666072
DOI: 10.1186/s12920-019-0591-7
PMCID: PMC6821037

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