Article
Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis.
Stroke - 1 Feb 2018
Laarman Melanie D, Vermunt Marit W, Kleinloog Rachel, de Boer-Bergsma Jelkje J, Brain Bank Netherlands, Rinkel Gabriël J E, Creyghton Menno P, Mokry Michal, Bakkers Jeroen, Ruigrok Ynte M
Abstract excerpt
BACKGROUND AND PURPOSE: Genome-wide association studies significantly link intracranial aneurysm (IA) to single-nucleotide polymorphisms (SNPs) in 6 genomic loci. To gain insight into the relevance of these IA-associated SNPs, we aimed to identify regulatory regions and analyze overall gene expression in the human circle of Willis (CoW), on which these aneurysms develop. METHODS: We performed chromatin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.