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Article

Distinct neural signatures of pulvinar in C9orf72 amyotrophic lateral sclerosis mutation carriers and noncarriers.

European journal of neurology - 1 Jun 2024

Nigri Anna, Stanziano Mario, Fedeli Davide, Manera Umberto, Ferraro Stefania, Medina Carrion Jean Paul, Palermo Sara, Lequio Laura, Denegri Federica, Agosta Federica, Spinelli Edoardo Gioele, Filippi Massimo, Grisoli Marina, Valentini Maria Consuelo, De Mattei Filippo, Canosa Antonio, Calvo Andrea, Chiò Adriano, Bruzzone Maria Grazia, Moglia Cristina

Abstract excerpt

BACKGROUND AND PURPOSE: Thalamic alterations have been reported as a major feature in presymptomatic and symptomatic patients carrying the C9orf72 mutation across the frontotemporal dementia-amyotrophic lateral sclerosis (ALS) spectrum. Specifically, the pulvinar, a high-order thalamic nucleus and timekeeper for large-scale cortical networks, has been hypothesized to be involved in C9orf72-related...

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PMID: 38469975
DOI: 10.1111/ene.16266
PMCID: PMC11235848

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