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Phenotypic differences in the inner ears of CBA/CaJ and C57BL/6J mice carrying missense and single base pair deletion mutations in the Cdh23 gene.

Journal of neuroscience research - 1 Oct 2021

Zhao Tong, Ma Peng, Zhao Fangfang, Zheng Tihua, Yan Bin, Zhang Qiang, Yuan Jing, Hu Bing, Yang Ying, Hu Juan, Geng Ruishuang, Hu Bo Hua, Sun Tengyang, Zheng Qing Yin, Li Bo

Abstract excerpt

Different mutations in the cadherin 23 (CDH23) gene in different genetic backgrounds have been linked to either syndromic or nonsyndromic forms of deafness in humans. We previously reported a progressive hearing loss (HL) mouse model, the Cdh23erl/erl mouse, which carries a 208T > C mutation causing an amino acid substitution at S70P in C57BL/6J mice. To investigate the differences in Cdh23 mutation-related HL in...

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PMID: 34133797
DOI: 10.1002/jnr.24905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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