Impacts of an age-related hearing loss allele of cadherin 23 on severity of hearing loss in ICR and NOD/Shi mice.

doi:10.1016/j.bbrc.2023.07.003

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Article

Impacts of an age-related hearing loss allele of cadherin 23 on severity of hearing loss in ICR and NOD/Shi mice.

Biochemical and biophysical research communications - 24 Sept 2023

Hou Xuehan, Yasuda Shumpei P, Yamaguchi Midori, Suzuki Sari, Seki Yuta, Ouchi Takafumi, Mao Ting, Prakhongcheep Ornjira, Shitara Hiroshi, Kikkawa Yoshiaki

Abstract excerpt

The age-related hearing loss allele (Cdh23ahl) of the cadherin 23 gene leads to a more severe hearing loss phenotype through additive effects with risk alleles for hearing loss. In this study, we genome edited the Cdh23ahl allele to the wild-type Cdh23+ allele in outbred ICR mice and inbred NOD/Shi mice established from ICR mice and investigated their effects on hearing phenotypes. Several hearing tests confirmed...

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