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Article

A mutation in the cdh23 gene causes age-related hearing loss in Cdh23(nmf308/nmf308) mice.

Gene - 15 May 2012

Liu Siwei, Li Shengli, Zhu Hongliang, Cheng Shaoli, Zheng Qing Yin

Abstract excerpt

Cadherin 23 (CDH23) is an important constituent of the hair cell tip link in the organ of Corti. Mutations in cdh23 are associated with age-related hearing loss (AHL). In this study, we proposed that the Cdh23(nmf308/nmf308) mice with progressive hair cell loss had specific morphological changes and suffered a base to apex gradient and age-related hearing loss, and that mutations in cdh23 were linked to AHL. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22326520
DOI: 10.1016/j.gene.2012.01.084
PMCID: PMC3526976

Genes

ABR
CDH23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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