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Article

Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice.

Hearing research - 1 Jan 2012

Kane Kelly L, Longo-Guess Chantal M, Gagnon Leona H, Ding Dalian, Salvi Richard J, Johnson Kenneth R

Abstract excerpt

Inbred strain variants of the Cdh23 gene have been shown to influence the onset and progression of age-related hearing loss (AHL) in mice. In linkage backcrosses, the recessive Cdh23 allele (ahl) of the C57BL/6J strain, when homozygous, confers increased susceptibility to AHL, while the dominant allele (Ahl+) of the CBA/CaJ strain confers resistance. To determine the isolated effects of these alleles on different...

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Identifiers

PMID: 22138310
DOI: 10.1016/j.heares.2011.11.007
PMCID: PMC3277672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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