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Asparaginyl Ligase-Catalyzed One-Step Cell Surface Modification of Red Blood Cells.

ACS chemical biology - 16 Jul 2021

Harmand Thibault J, Pishesha Novalia, Rehm Fabian B H, Ma Weiyi, Pinney William B, Xie Yushu J, Ploegh Hidde L

Abstract excerpt

Red blood cells (RBCs) can serve as vascular carriers for drugs, proteins, peptides, and nanoparticles. Human RBCs remain in the circulation for ∼120 days, are biocompatible, and are immunologically largely inert. RBCs are cleared by the reticuloendothelial system and can induce immune tolerance to foreign components attached to the RBC surface. RBC conjugates have been pursued in clinical trials to treat cancers...

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Identifiers

PMID: 34129316
DOI: 10.1021/acschembio.1c00216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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