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Article

Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow.

Nature reviews. Cancer - 1 Sept 2018

Gillies Robert J, Brown Joel S, Anderson Alexander R A, Gatenby Robert A

Abstract excerpt

Temporal changes in blood flow are commonly observed in malignant tumours, but the evolutionary causes and consequences are rarely considered. We propose that stochastic temporal variations in blood flow and microenvironmental conditions arise from the eco-evolutionary dynamics of tumour angiogenesis in which cancer cells, as individual units of selection, can influence and respond only to local environmental...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29891961
DOI: 10.1038/s41568-018-0030-7
PMCID: PMC6441333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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