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Article

Droplet digital PCR assay for detecting TERT promoter mutations in patients with glioma.

Brain tumor pathology - 1 Jul 2021

Adachi Jun-Ichi, Shirahata Mitsuaki, Suzuki Tomonari, Mishima Kazuhiko, Uchida Eita, Sasaki Atsushi, Nishikawa Ryo

Abstract excerpt

Two hot spot mutations (C228T, C250T) in the telomerase reverse transcriptase (TERT) gene are frequently identified in glioblastoma and oligodendroglioma. TERT mutations predicts an aggressive clinical course in isocitrate dehydrogenase (IDH) wild-type astrocytic tumors. Therefore, it is important to accurately detect TERT promoter mutations in glioma. Sanger DNA sequencing is the currently standard method for...

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Identifiers

PMID: 34128111
DOI: 10.1007/s10014-021-00403-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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