Article
Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas.
Neuro-oncology - 18 Mar 2019
Diplas Bill H, Liu Heng, Yang Rui, Hansen Landon J, Zachem Alexis L, Zhao Fangping, Bigner Darell D, McLendon Roger E, Jiao Yuchen, He Yiping, Waitkus Matthew S, Yan Hai
Abstract excerpt
BACKGROUND: Mutations in telomerase reverse transcriptase promoter (TERTp) and isocitrate dehydrogenase 1 and 2 (IDH) offer objective markers to assist in classifying diffuse gliomas into genetic subgroups. However, traditional mutation detection techniques lack sensitivity or have long turnaround times or high costs. We developed GliomaDx, an allele-specific, locked nucleic acid-based quantitative PCR assay to...
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