Article
Analysis of TERT promoter hotspot mutations using droplet digital PCR in hepatoblastoma and hepatocellular carcinoma.
Mutation research - 1 Jan 2025
Hiyama Yoko, Kojima Masato, Kurihara Sho, Saeki Isamu, Touge Ryo, Fukazawa Takahiro, Harada Takanori, Hiyama Eiso
Abstract excerpt
Somatic mutations in the telomerase reverse transcriptase promoter (TERTp) region are common in many cancers, including in liver cancers. Detection of TERTp mutations in tumor tissue DNAs and cell-free tumor DNAs is useful for diagnosing and monitoring cancers. Since the most common TERTp hotspot mutations, C228T and C250T, are difficult to identify using Sanger sequencing, we tested an easy and highly sensitive...
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