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Article

Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.

Nature microbiology - 1 Jul 2021

Xu Xin, Peng Ruchao, Peng Qi, Wang Min, Xu Ying, Liu Sheng, Tian Xiaolin, Deng Haiteng, Tong Yimin, Hu Xiaoyou, Zhong Jin, Wang Peiyi, Qi Jianxun, Gao George F, Shi Yi

Abstract excerpt

Zoonotic arenaviruses can lead to life-threating diseases in humans. These viruses encode a large (L) polymerase that transcribes and replicates the viral genome. At the late stage of replication, the multifunctional Z protein interacts with the L polymerase to shut down RNA synthesis and initiate virion assembly. However, the mechanism by which the Z protein regulates the activity of L polymerase is unclear....

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PMID: 34127846
DOI: 10.1038/s41564-021-00916-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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