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Structure of Machupo virus polymerase in complex with matrix protein Z

25 Oct 2021

Abstract excerpt

The Arenaviridae family includes several viruses that cause severe human hemorrhagic fevers with high mortality, with no effective countermeasures currently available. The arenavirus multi-domain L protein is involved in viral transcription and replication and represents a promising target for antiviral drugs. The arenavirus matrix protein Z is a small multi-functional protein that inhibits the activities of the...

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PMID: 34697302
DOI: 10.1038/s41467-021-26432-3

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