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Structural basis for recognition and regulation of arenavirus polymerase L by Z protein

5 Jul 2021

Abstract excerpt

Junin virus (JUNV) causes Argentine hemorrhagic fever, a debilitating human disease of high mortality rates and a great risk to public health worldwide. Studying the L protein that replicates and transcribes the genome of JUNV, and its regulator Z protein should provide critical clues to identify therapeutic targets for disrupting the life cycle of JUNV. Here we report the 3.54 Å cryo-EM structure of the JUNV L...

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PMID: 34226547
DOI: 10.1038/s41467-021-24458-1

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