Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Arenavirus Z protein controls viral RNA synthesis by locking a polymerase–promoter complex

21 Nov 2011

Abstract excerpt

Arenaviruses form a noncytolytic infection in their rodent hosts, yet can elicit severe hemorrhagic disease in humans. How arenaviruses regulate gene expression remains unclear, and further understanding may provide insight into the dichotomy of these disparate infection processes. Here we reconstitute arenavirus RNA synthesis initiation and gene expression regulation in vitro using purified components and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Viral gastroenteritis research and epidemiology
Share to Viral Infections and Outbreaks Research
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22106304
DOI: 10.1073/pnas.1112742108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Arenavirus Z protein controls viral RNA synthesis by locking a polymerase–promoter complexPMID 22106304Read ↗

Biological Roles and Functional Mechanisms of Arenavirus Z Protein in Viral ReplicationSemantic proximity Read ↗

Multifunctional Nature of the Arenavirus RING Finger Protein ZSemantic proximity Read ↗

Structure of Machupo virus polymerase in complex with matrix protein ZSemantic proximity Read ↗

Molecular Mechanism of Arenavirus Assembly and BuddingSemantic proximity Read ↗

Structural basis for recognition and regulation of arenavirus polymerase L by Z proteinSemantic proximity Read ↗

Cells Expressing the RING Finger Z Protein Are Resistant to Arenavirus InfectionSemantic proximity Read ↗

The C-Terminal Region of Lymphocytic Choriomeningitis Virus Nucleoprotein Contains Distinct and Segregable Functional Domains Involved in NP-Z Interaction and Counteraction of the Type I Interferon ResponseSemantic proximity Read ↗

The Z Proteins of Pathogenic but Not Nonpathogenic Arenaviruses Inhibit RIG-i-Like Receptor-Dependent Interferon ProductionSemantic proximity Read ↗

Architecture and regulation of negative-strand viral enzymatic machinerySemantic proximity Read ↗

Identification of Two Functional Domains within the Arenavirus NucleoproteinSemantic proximity Read ↗

Molecular determinants of arenavirus Z protein homo-oligomerization and L polymerase binding.Semantic proximity Read ↗

The RING Domain and the L79 Residue of Z Protein Are Involved in both the Rescue of Nucleocapsids and the Incorporation of Glycoproteins into Infectious Chimeric Arenavirus-Like ParticlesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.