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Article

Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein

20 Dec 2017

Abstract excerpt

RNA-dependent RNA polymerases (RdRps) play a key role in the life cycle of RNA viruses and impact their immunobiology. The arenavirus lymphocytic choriomeningitis virus (LCMV) strain Clone 13 provides a benchmark model for studying chronic infection. A major genetic determinant for its ability to persist maps to a single amino acid exchange in the viral L protein, which exhibits RdRp activity, yet its functional...

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PMID: 29261807
DOI: 10.1371/journal.ppat.1006758

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