Structural insights into the RNA-dependent RNA polymerase complexes from highly pathogenic Marburg and Ebola viruses

Abstract excerpt

The Ebola and the Marburg viruses belong to the Filoviridae family, a group of filamentous, single-stranded, negative-sensed RNA viruses. Upon infection, uncontrolled propagation of the Ebola and the Marburg viruses causes severe hemorrhagic fevers with high mortality rates. The replication and transcription of viral genomes are mediated by a polymerase complex consisting of two proteins: L and its cofactor VP35....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to COVID-19 epidemiological studies
• Share to Viral Infections and Outbreaks Research
• Share to Viral Infections and Vectors