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Article

Biological Roles and Functional Mechanisms of Arenavirus Z Protein in Viral Replication

4 Jul 2012

Abstract excerpt

Arenaviruses can cause severe hemorrhagic fever diseases in humans, with limited prophylactic or therapeutic measures. A small RING-domain viral protein Z has been shown to mediate the formation of virus-like particles and to inhibit viral RNA synthesis, although its biological roles in an infectious viral life cycle have not been directly addressed. By taking advantage of the available reverse genetics system...

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PMID: 22761375
DOI: 10.1128/jvi.00385-12

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