Article
Maintenance of the human memory T cell repertoire by subset and tissue site.
Genome medicine - 14 Jun 2021
Miron Michelle, Meng Wenzhao, Rosenfeld Aaron M, Dvorkin Shirit, Poon Maya Meimei Li, Lam Nora, Kumar Brahma V, Louzoun Yoram, Luning Prak Eline T, Farber Donna L
Abstract excerpt
BACKGROUND: Immune-mediated protection is mediated by T cells expressing pathogen-specific T cell antigen receptors (TCR) that are maintained at diverse sites of infection as tissue-resident memory T cells (TRM) or that disseminate as circulating effector-memory (TEM), central memory (TCM), or terminal effector (TEMRA) subsets in blood and tissues. The relationship between circulating and tissue resident T cell...
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