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Article

Study on Environmental Causes and SNPs of MTHFR, MS and CBS Genes Related to Congenital Heart Disease.

PloS one - 1 Jan 2015

Shi Hui, Yang Shiwei, Liu Yan, Huang Peng, Lin Ning, Sun Xiaoru, Yu Rongbin, Zhang Yuanyuan, Qin Yuming, Wang Lijuan

Abstract excerpt

PURPOSE: Congenital heart diseases (CHD) are among the most common birth defects in China. Environmental causes and folate metabolism changes may alter susceptibility to CHD. The aim of this study is to evaluate the relevant risk-factors of children with CHD and their mothers. METHODS: 138 children with CHD and 207 normal children for controls were recruited. Their mothers were also enlisted in this study and...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Cystathionine beta-Synthase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Environmental Exposure

Share to Folic Acid

Share to Heart Defects, Congenital

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Share to Metabolic Networks and Pathways

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Source

Open in PubMed Open full text

Identifiers

PMID: 26035828
DOI: 10.1371/journal.pone.0128646
PMCID: PMC4452709

Genes

MTHFR
CBS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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