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Article

Association of MTHFR C677T variant genotype with serum folate and Vit B12 in Iranian patients with colorectal cancer or adenomatous polyps.

BMC medical genomics - 13 Oct 2021

Ghorbani Mahla, Azghandi Marjan, Khayami Reza, Baharara Javad, Kerachian Mohammad Amin

Abstract excerpt

BACKGROUND: The incidence of colorectal cancer (CRC) has increased during recent years in Iran and other developing countries. Clinical studies suggest that essential folate dietary intake and moderate deficiency of methylenetetrahydrofolate reductase (MTHFR) may protect and reduce the risk of CRC. The present study aimed to investigate the clinical significance of C677T polymorphism within the MTHFR gene and its...

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Source

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Identifiers

PMID: 34645434
DOI: 10.1186/s12920-021-01097-5
PMCID: PMC8513199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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