Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

JAK2-IGF1 axis in osteoclasts regulates postnatal growth in mice.

JCI insight - 8 Mar 2021

Dodington David W, Yumol Jenalyn L, Yang Jiaqi, Pollock-Tahiri Evan, Sivasubramaniyam Tharini, Sacco Sandra M, Schroer Stephanie A, Li Yujin E, Le Helen, Ward Wendy E, Woo Minna

Abstract excerpt

Osteoclasts are specialized cells of the hematopoietic lineage that are responsible for bone resorption and play a critical role in musculoskeletal disease. JAK2 is a key mediator of cytokine and growth factor signaling; however, its role in osteoclasts in vivo has yet to be investigated. To elucidate the role of JAK2 in osteoclasts, we generated an osteoclast-specific JAK2-KO (Oc-JAK2-KO) mouse using the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Osteoclasts
Share to Body Size

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone and Bones

Share to Bone Density

Share to Bone Resorption

Share to Insulin-Like Growth Factor I

Share to Janus Kinase 2

Source

Open in PubMed Open full text

Identifiers

PMID: 33682794
DOI: 10.1172/jci.insight.137045
PMCID: PMC8021113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

JAK2-IGF1 axis in osteoclasts regulates postnatal growth in mice.PMID 33682794Read ↗

Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts.Semantic proximity Read ↗

Systemic Jak1 activation causes extrarenal calcitriol production and skeletal alterations provoking stunted growth.Semantic proximity Read ↗

Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations.Semantic proximity Read ↗

Mef2c deletion in osteocytes results in increased bone mass.Semantic proximity Read ↗

The loss of STAT3 in mature osteoclasts has detrimental effects on bone structureSemantic proximity Read ↗

Mst2 Controls Bone Homeostasis by Regulating Osteoclast and Osteoblast Differentiation.Semantic proximity Read ↗

In Vivo Targeting of the Growth Hormone Receptor (GHR) Box1 Sequence Demonstrates that the GHR Does Not Signal Exclusively through JAK2Semantic proximity Read ↗

Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formationSemantic proximity Read ↗

JAK-STAT and bone metabolismSemantic proximity Read ↗

Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization.Semantic proximity Read ↗

Increased Osteoclast Activity Contributes to Bone Resorption and Osteopenia in a Rett Syndrome Mouse ModelSemantic proximity Read ↗

SOCS2 is the critical regulator of GH action in murine growth plate chondrogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.