Article
The PHF21B gene is associated with major depression and modulates the stress response.
Molecular psychiatry - 1 Jul 2017
Wong M-L, Arcos-Burgos M, Liu S, Vélez J I, Yu C, Baune B T, Jawahar M C, Arolt V, Dannlowski U, Chuah A, Huttley G A, Fogarty R, Lewis M D, Bornstein S R, Licinio J
Abstract excerpt
Major depressive disorder (MDD) affects around 350 million people worldwide; however, the underlying genetic basis remains largely unknown. In this study, we took into account that MDD is a gene-environment disorder, in which stress is a critical component, and used whole-genome screening of functional variants to investigate the 'missing heritability' in MDD. Genome-wide association studies (GWAS) using single-...
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