Article
Association between depression and the Gln460Arg polymorphism of P2RX7 gene: a dimensional approach.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2009
Hejjas Krisztina, Szekely Anna, Domotor Eszter, Halmai Zsuzsa, Balogh Gabriella, Schilling Boglarka, Sarosi Andrea, Faludi Gabor, Sasvari-Szekely Maria, Nemoda Zsofia
Abstract excerpt
The P2RX7 gene (coding for P2X7 purinergic receptor) has been suggested as a novel candidate gene for major depressive disorder (MDD) and bipolar disorder (BPD). The proposed risk allele (G-allele) of the rs2230912 polymorphism results in an amino acid change at the 460th position, marking this genetic variation a possibly functional one. Here we present a case-control analysis of 171 patients diagnosed with MDD...
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