Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection.

doi:10.1038/s41591-021-01371-0

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Article

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection.

Nature medicine - 1 Jun 2021

Zekavat Seyedeh M, Lin Shu-Hong, Bick Alexander G, Liu Aoxing, Paruchuri Kaavya, Wang Chen, Uddin Md Mesbah, Ye Yixuan, Yu Zhaolong, Liu Xiaoxi, Kamatani Yoichiro, Bhattacharya Romit, Pirruccello James P, Pampana Akhil, Loh Po-Ru, Kohli Puja, McCarroll Steven A, Kiryluk Krzysztof, Neale Benjamin, Ionita-Laza Iuliana, Engels Eric A, Brown Derek W, Smoller Jordan W, Green Robert, Karlson Elizabeth W, Lebo Matthew, Ellinor Patrick T, Weiss Scott T, Daly Mark J, Terao Chikashi, Zhao Hongyu, Ebert Benjamin L, Reilly Muredach P, Ganna Andrea, Machiela Mitchell J, Genovese Giulio, Natarajan Pradeep

Abstract excerpt

Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to infectious disease risk are incompletely understood. Age-related mosaic chromosomal alterations (mCAs) detected from genotyping of blood-derived DNA, are structural somatic variants indicative of clonal hematopoiesis, and are associated with aberrant leukocyte cell counts, hematological malignancy, and mortality. Here, we...

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PMID: 34099924
DOI: 10.1038/s41591-021-01371-0
PMCID: PMC8245201

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