Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants.

doi:10.1038/s41586-021-03676-z

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Article

Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants.

Nature - 1 Jul 2021

Xu Jianliang, Xu Kai, Jung Seolkyoung, Conte Andrea, Lieberman Jenna, Muecksch Frauke, Lorenzi Julio Cesar Cetrulo, Park Solji, Schmidt Fabian, Wang Zijun, Huang Yaoxing, Luo Yang, Nair Manoj S, Wang Pengfei, Schulz Jonathan E, Tessarollo Lino, Bylund Tatsiana, Chuang Gwo-Yu, Olia Adam S, Stephens Tyler, Teng I-Ting, Tsybovsky Yaroslav, Zhou Tongqing, Munster Vincent, Ho David D, Hatziioannou Theodora, Bieniasz Paul D, Nussenzweig Michel C, Kwong Peter D, Casellas Rafael

Abstract excerpt

Since the start of the COVID-19 pandemic, SARS-CoV-2 has caused millions of deaths worldwide. Although a number of vaccines have been deployed, the continual evolution of the receptor-binding domain (RBD) of the virus has challenged their efficacy. In particular, the emerging variants B.1.1.7, B.1.351 and P.1 (first detected in the UK, South Africa and Brazil, respectively) have compromised the efficacy of sera...

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Identifiers

PMID: 34098567
DOI: 10.1038/s41586-021-03676-z
PMCID: PMC8260353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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