Article

Nanobodies against SARS-CoV-2 reduced virus load in the brain of challenged mice and neutralized Wuhan, Delta and Omicron Variants

2023-03-14

Abstract excerpt

In this work, we developed llama-derived nanobodies (Nbs) directed to the receptor binding domain (RBD) and other domains of the Spike (S) protein of SARS-CoV-2. Nanobodies were selected after the biopanning of two VHH-libraries, one of which was generated after the immunization of a llama ( lama glama ) with the bovine coronavirus (BCoV) Mebus, and another with the full-length pre-fused locked S protein (S-2P) a...

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Identifiers and source

Literature Corpus work: 31330388-1aa8-52a7-a9e0-00a9fb607dc7
DOI: 10.1101/2023.03.14.532528

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