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Article

Association of Common and Rare Genetic Variation in the 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene and Cataract Risk.

Journal of the American Heart Association - 21 Jun 2022

Ghouse Jonas, Ahlberg Gustav, Skov Anne Guldhammer, Bundgaard Henning, Olesen Morten S

Abstract excerpt

Background Results from animal models and observational studies have raised concerns regarding the potential cataractogenic effects of statin treatment. We investigated whether common and rare genetic variants in HMGCR are associated with cataract risk, to gauge the likely long-term effects of statin treatment on lenticular opacities. Methods and Results We used genotyping data and exome sequencing data of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35703387
DOI: 10.1161/JAHA.122.025361
PMCID: PMC9238641

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