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Article

Effects of genetically proxied statins on diabetic nephropathy and retinopathy: a Mendelian randomization study.

Scientific reports - 23 Jul 2024

Zhao Ran, Wang WeiLi, Zhang Wen, Lu JiaPeng, Liu Yi, Guo Jing, Yang Lu, Zhang ZeDan, He Chang, Gu XinYi, Wang Bin

Abstract excerpt

There is no reliable causal evidence for the effect of statins on diabetic nephropathy (DN) and diabetic retinopathy (DR), and the results of previous observational studies are contradictory. Genetic variants linked to low-density lipoprotein cholesterol (LDL-C) from a UK biobank genome-wide association study and located within a 100kb window around HMGCR were used to proxy statins, comparing with PCSK9...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

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Source

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Identifiers

PMID: 39043809
DOI: 10.1038/s41598-024-67800-5
PMCID: PMC11266622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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