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Article

Associations of Lipid-Lowering Drugs With Blood Pressure and Fasting Glucose: A Mendelian Randomization Study.

Hypertension (Dallas, Tex. : 1979) - 1 Apr 2025

Song Beiping, Sun Lulu, Qin Xiaoli, Fei Jiawen, Yu Quan, Chang Xinyue, He Yu, Liu Yi, Shi Mengyao, Guo Daoxia, Shen Ouxi, Zhu Zhengbao

Abstract excerpt

BACKGROUND: Observational studies have linked LDL-C (low-density lipoprotein-cholesterol)-lowering drugs with lower blood pressure (BP) and higher fasting glucose, but the causality remains unclear. We conducted a drug target Mendelian randomization study to assess the causal associations of genetically proxied inhibition of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), PCSK9 (proprotein convertase...

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Share to Blood Glucose
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

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Source

Identifiers

PMID: 39902581
DOI: 10.1161/HYPERTENSIONAHA.124.23829

Genes

HMGCR
NPC1L1
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

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