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The interaction between common genetic mutations in AML and the immune landscape: mechanisms and implications for immune response

11 Aug 2025

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy driven by diverse genetic mutations that shape tumor progression, immune evasion, and clinical outcomes. While molecular profiling has improved AML classification, the precise impact of specific mutations on immune cell infiltration and dysregulation remains insufficiently understood. This review examines the immunologic consequences of common...

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PMID: 40861464
DOI: 10.3389/fimmu.2025.1635111

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