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Article

Reliable Resolution of Full-Length Huntingtin Alleles by Quantitative Immunoblotting.

Journal of Huntington's disease - 1 Jan 2021

Caron Nicholas S, Anderson Christine, Black Hailey Findlay, Sanders Shaun S, Lemarié Fanny L, Doty Crystal N, Hayden Michael R

Abstract excerpt

BACKGROUND: Therapeutics that lower mutant huntingtin (mHTT) have shown promise in preclinical studies and are in clinical development for the treatment of Huntington disease (HD). Multiple assays have been developed that either quantify mHTT or total HTT but may not accurately measure levels of wild type HTT (wtHTT) in biological samples. OBJECTIVE: To optimize a method that can be used to resolve, quantify and...

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PMID: 34092649
DOI: 10.3233/JHD-200463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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